CD22































































CD22
Identifiers
Aliases
CD22, SIGLEC-2, SIGLEC2, CD22 molecule
External IDs OMIM: 107266 MGI: 88322 HomoloGene: 31052 GeneCards: CD22


















Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]

Chromosome 19 (human)
Genomic location for CD22

Genomic location for CD22

Band 19q13.12 Start 35,319,261 bp[1]
End 35,347,355 bp[1]























RNA expression pattern

PBB GE CD22 204581 at fs.png

PBB GE CD22 217422 s at fs.png

PBB GE CD22 38521 at fs.png
More reference expression data















Orthologs
Species Human Mouse
Entrez


933


12483
Ensembl


ENSG00000012124


ENSMUSG00000030577
UniProt


P20273


P35329
RefSeq (mRNA)





NM_001043317
NM_009845
RefSeq (protein)


NP_001172028
NP_001172029
NP_001172030
NP_001265346
NP_001762


NP_001036782
NP_033975
Location (UCSC) Chr 19: 35.32 – 35.35 Mb Chr 7: 30.87 – 30.88 Mb

PubMed search		 [3] [4]
Wikidata



View/Edit Human View/Edit Mouse

CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins.[5] It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.[6]


CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.[7]


An immunotoxin, BL22, that targets this receptor is being tested at the NIH.[8]



Interactions


CD22 has been shown to interact with Grb2,[9][10]PTPN6,[10][11][12][13][14]LYN,[9][12]SHC1[9] and INPP5D.[9]



References





  1. ^ abc GRCh38: Ensembl release 89: ENSG00000012124 - Ensembl, May 2017


  2. ^ abc GRCm38: Ensembl release 89: ENSMUSG00000030577 - Ensembl, May 2017


  3. ^ "Human PubMed Reference:"..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}


  4. ^ "Mouse PubMed Reference:".


  5. ^ Crocker PR, et al. (February 1998). "Siglecs: a family of sialic-acid binding lectins". Glycobiology. 8 (2): v. doi:10.1093/glycob/8.2.0. PMID 9498912.


  6. ^ Hatta; et al. (1999). "Identification of the gene variations in human CD22". Immunogenetics. 49 (4): 280–286. doi:10.1007/s002510050494.


  7. ^ Lee M, Kiefel H, LaJevic MD, Macauley MS, Kawashima H, O'Hara E, Pan J, Paulson JC, Butcher EC (October 2014). "Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing". Nature Immunology. 15 (10): 982–95. doi:10.1038/ni.2983. PMC 4222088. PMID 25173345.


  8. ^ "BL22 Immunotoxin in Treating Patients Previously Treated With Cladribine for Hairy Cell Leukemia". ClinicalTrials.gov - U.S. National Institutes of Health. Retrieved 2008-02-19.


  9. ^ abcd Poe JC, Fujimoto M, Jansen PJ, Miller AS, Tedder TF (June 2000). "CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux". The Journal of Biological Chemistry. 275 (23): 17420–7. doi:10.1074/jbc.M001892200. PMID 10748054.


  10. ^ ab Otipoby KL, Draves KE, Clark EA (November 2001). "CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1". The Journal of Biological Chemistry. 276 (47): 44315–22. doi:10.1074/jbc.M105446200. PMID 11551923.


  11. ^ Blasioli J, Paust S, Thomas ML (January 1999). "Definition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22". The Journal of Biological Chemistry. 274 (4): 2303–7. doi:10.1074/jbc.274.4.2303. PMID 9890995.


  12. ^ ab Greer SF, Justement LB (May 1999). "CD45 regulates tyrosine phosphorylation of CD22 and its association with the protein tyrosine phosphatase SHP-1". Journal of Immunology. 162 (9): 5278–86. PMID 10228003.


  13. ^ Law CL, Sidorenko SP, Chandran KA, Zhao Z, Shen SH, Fischer EH, Clark EA (February 1996). "CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation". The Journal of Experimental Medicine. 183 (2): 547–60. doi:10.1084/jem.183.2.547. PMC 2192439. PMID 8627166.


  14. ^ Adachi T, Wienands J, Wakabayashi C, Yakura H, Reth M, Tsubata T (July 2001). "SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates". The Journal of Biological Chemistry. 276 (28): 26648–55. doi:10.1074/jbc.M100997200. PMID 11356834.




External links




  • CD22+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)

  • Human CD22 genome location and CD22 gene details page in the UCSC Genome Browser.














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