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Balancer chromosomes are special, modified chromosomes used for genetically screening a population of organisms to select for heterozygotes. Balancer chromosomes can be used as a genetic tool to prevent crossing over (genetic recombination) between homologous chromosomes during meiosis. Balancers are most often used in Drosophila melanogaster (fruit fly) genetics to allow populations of flies carrying heterozygous mutations to be maintained without constantly screening for the mutations but can also be used in mice. [1] Balancer chromosomes have three important properties: they suppress recombination with their homologs, carry dominant markers, and negatively affect reproductive fitness when carried homozygously. Contents 1 History of balancer chromosomes 2 How balancer chromosomes work 3 Naming convention 4 Important scientific contributions using balancer chromosomes 5 References History of balancer chromosomes Balancer chromosomes were first ...

In genetics, Flp- FRT recombination is a site-directed recombination technology, increasingly used to manipulate an organism's DNA under controlled conditions in vivo . It is analogous to Cre- lox recombination but involves the recombination of sequences between short flippase recognition target ( FRT ) sites by the recombinase flippase(Flp)derived from the 2 µm plasmid of baker's yeast Saccharomyces cerevisiae . The 34bp minimal FRT site sequence has the sequence 5' GAAGTTCCTATTC tctagaaa G t ATAGGAACTTC 3' for which flippase (Flp) binds to both 13-bp 5'-GAAGTTCCTATTC-3' arms flanking the 8 bp spacer, i.e. the site-specific recombination (region of crossover) in reverse orientation. FRT -mediated cleavage occurs just ahead from the asymmetric 8bp core region ( 5' tctagaaa 3' ) on the top strand and behind this sequence on the bottom strand. [1] Several variant FRT sites exist, but recombination can usually occur only between two identic...

Lady Megan Lloyd George CH MP Member of Parliament for Carmarthen In office 28 February 1957 – 14 May 1966 Preceded by Rhys Hopkin Morris Succeeded by Gwynfor Evans Deputy Leader of the Liberal Party In office 1949–1950 Leader Clement Davies Preceded by Percy Harris (1945) Succeeded by Donald Wade (1962) Member of Parliament for Anglesey In office 30 May 1929 – 24 October 1951 Preceded by Robert Thomas Succeeded by Cledwyn Hughes Personal details Born Megan Arvon George ( 1902-04-22 ) 22 April 1902 Criccieth, Caernarfonshire (present-day Gwynedd) Died 14 May 1966 (1966-05-14) (aged 64) Pwllheli, Wales Nationality British Political party Liberal Party Labour Party Parents David Lloyd George Margaret Owen Lady Megan Arvon Lloyd George , CH (22 April 1902 – 14 May 1966), born Megan Arvon George , was a Welsh politician, who became the first female Member of Parliament (MP) for a Welsh consti...

Hopkin Morris Sir Rhys Hopkin Morris (5 September 1888 – 22 November 1956) was a Welsh Liberal politician who was a Member of Parliament from 1923–1932 and from 1945–1956. Contents 1 Early life 2 Political career 3 See also 4 Notes 5 References 6 Further reading 7 External links Early life Morris was born at Blaencaerau, Maesteg, Glamorgan, son of John Morris, Congregational minister in Caerau, and Mary. [1] He was educated at University of Wales, Bangor and at University College London from 1913-1914, graduating with Honours in Philosophy. He was admitted to Middle Temple on 10 January 1914. Morris served continually in the armed forces during the First World War from December 1914 until January 1919, possessing the rank of Lieutenant in the 2nd Battalion Royal Welsh Fusiliers by the end of the war and being twice wounded - the second time seriously. He was mentioned in dispatches and awarded the Order of the British Empire (milita...