ER |
Agonists |
Steroidal: 2-Hydroxyestradiol
- 2-Hydroxyestrone
- 3-Methyl-19-methyleneandrosta-3,5-dien-17β-ol
- 3α-Androstanediol
- 3α,5α-Dihydrolevonorgestrel
- 3β,5α-Dihydrolevonorgestrel
- 3α-Hydroxytibolone
- 3β-Hydroxytibolone
- 3β-Androstanediol
- 4-Androstenediol
- 4-Androstenedione
- 4-Hydroxyestradiol
- 4-Hydroxyestrone
- 4-Methoxyestradiol
- 4-Methoxyestrone
- 5-Androstenediol
- 7-Oxo-DHEA
- 7α-Hydroxy-DHEA
- 7α-Methylestradiol
- 7β-Hydroxyepiandrosterone
- 8,9-Dehydroestradiol
- 8,9-Dehydroestrone
- 8β-VE2
- 10β,17β-Dihydroxyestra-1,4-dien-3-one (DHED)
- 16α-Fluoroestradiol
- 16α-Hydroxy-DHEA
- 16α-Hydroxyestrone
- 16α-Iodoestradiol
- 16α-LE2
- 16β,17α-Epiestriol (16β-hydroxy-17α-estradiol)
17α-Estradiol (alfatradiol)
- 17α-Dihydroequilenin
- 17α-Dihydroequilin
- 17α-Epiestriol (16α-hydroxy-17α-estradiol)
- 17β-Dihydroequilenin
- 17β-Dihydroequilin
- Abiraterone
- Abiraterone acetate
- Alestramustine
- Almestrone
Anabolic steroids (e.g., testosterone and esters, methyltestosterone, metandienone (methandrostenolone), nandrolone and esters, many others; via estrogenic metabolites)
- Atrimustine
- Bolandiol
- Bolandiol dipropionate
- Butolame
- Clomestrone
Cloxestradiol
- Conjugated estrogens
- Cyclodiol
- Cyclotriol
- DHEA
- DHEA-S
- Epiestriol (16β-epiestriol, 16β-hydroxy-17β-estradiol)
- Epimestrol
- Equilenin
- Equilin
- ERA-63 (ORG-37663)
- Esterified estrogens
- Estetrol
Estradiol
- Estradiol esters
- Lipoidal estradiol
- Polyestradiol phosphate
- Estramustine
- Estramustine phosphate
- Estrapronicate
- Estrazinol
Estriol
- Estriol esters
- Polyestriol phosphate
- Estrofurate
- Estromustine
Estrone
- Estrone esters
- Estrone methyl ether
- Estropipate
- Etamestrol (eptamestrol)
Ethinylestradiol
- Ethinylestradiol 3-benzoate
- Ethinylestradiol sulfonate
- Ethinylestriol
- Ethylestradiol
- Etynodiol
- Etynodiol diacetate
- Hexolame
- Hippulin
- Hydroxyestrone diacetate
- Lynestrenol
- Lynestrenol phenylpropionate
- Mestranol
- Methylestradiol
- Moxestrol
- Mytatrienediol
- Nilestriol
- Norethisterone
- Noretynodrel
- Orestrate
- Pentolame
- Prodiame
- Prolame
- Promestriene
- RU-16117
- Quinestradol
- Quinestrol
- Tibolone
Nonsteroidal: (R,R)-THC
- (S,S)-THC
- 2,8-DHHHC
- β-LGND1
- β-LGND2 (GTx-878)
- AC-186
- Allenestrol
- Allenolic acid
- Benzestrol
- Bifluranol
- Bisdehydrodoisynolic acid
- Carbestrol
- D-15414
- DCW234
- Diarylpropionitrile
Dienestrol
Diethylstilbestrol
- Diethylstilbestrol esters
- Dimestrol (dianisylhexene)
- Doisynoestrol (fenocycline)
- Doisynolic acid
- Efavirenz
- ERB-196 (WAY-202196)
- Erteberel (SERBA-1, LY-500307)
- Estrobin (DBE)
- Fenestrel
- FERb 033
- Fosfestrol (diethylstilbestrol diphosphate)
- Furostilbestrol (diethylstilbestrol difuroate)
- GTx-758
Hexestrol
- ICI-85966 (Stilbostat)
- Mestilbol
- Methallenestril
- Methestrol
- Methestrol dipropionate
- Paroxypropione
- Pentafluranol
- Phenestrol
- Prinaberel (ERB-041, WAY-202041)
- Propylpyrazoletriol
- Quadrosilan
- SC-4289
- SERBA-2
- SKF-82,958
- Terfluranol
- Triphenylbromoethylene
- Triphenylchloroethylene
- Triphenyliodoethylene
- Triphenylmethylethylene (triphenylpropene)
- WAY-166818
- WAY-169916
- WAY-200070
- WAY-204688 (SIM-688)
- WAY-214156
Unknown/unsorted: ERB-26
- ERA-45
- ERB-79
- ZK-283197
Xenoestrogens: Anise-related (e.g., anethole, anol, dianethole, dianol, photoanethole)
Chalconoids (e.g., isoliquiritigenin, phloretin, phlorizin (phloridzin), wedelolactone)
Coumestans (e.g., coumestrol, psoralidin)
Flavonoids (incl. 7,8-DHF, 8-prenylnaringenin, apigenin, baicalein, baicalin, biochanin A, calycosin, catechin, daidzein, daidzin, ECG, EGCG, epicatechin, equol, formononetin, glabrene, glabridin, genistein, genistin, glycitein, kaempferol, liquiritigenin, mirificin, myricetin, naringenin, penduletin, pinocembrin, prunetin, puerarin, quercetin, tectoridin, tectorigenin)
- Lavender oil
Lignans (e.g., enterodiol, enterolactone, nyasol (cis-hinokiresinol))
Metalloestrogens (e.g., cadmium)
Pesticides (e.g., alternariol, dieldrin, endosulfan, fenarimol, methiocarb, methoxychlor, triclocarban, triclosan)
Phytosteroids (e.g., digitoxin (digitalis), diosgenin, guggulsterone)
Phytosterols (e.g., β-sitosterol, campesterol, stigmasterol)
Resorcylic acid lactones (e.g., zearalanone, α-zearalenol, β-zearalenol, zearalenone, zeranol (α-zearalanol), taleranol (teranol, β-zearalanol))
Steroid-like (e.g., deoxymiroestrol, miroestrol)
Stilbenoids (e.g., resveratrol, rhaponticin)
Synthetic xenoestrogens (e.g., alkylphenols, bisphenols (e.g., BPA, BPF, BPS), DDT, parabens, PBBs, PHBA, phthalates, PCBs)
- Others (e.g., agnuside, rotundifuran)
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Mixed (SERMs) |
- 2-Phenylbenzofuran
- 2-Phenylbenzothiophene
- 4'-Hydroxynorendoxifen
- 27-Hydroxycholesterol
- Acefluranol
- Acolbifene
- Afimoxifene
- Anordiol
- Anordrin
- Arzoxifene
- Bazedoxifene
- Brilanestrant
- Broparestrol
- Chlorotrianisene
- Clomifene
- Clomifenoxide
- Cyclofenil
- D-15413
- Droloxifene
- Elacestrant
- Enclomifene
- Endoxifen
- Etacstil (GW-5638, DPC-974)
- Ethamoxytriphetol (MER-25)
- Femarelle
- Fispemifene
- GW-7604
- ICI-55548
- Idoxifene
- Lasofoxifene
- Levormeloxifene
- LN-1643
- LN-2299
- LY-117018
- Menerba
- Miproxifene
- Miproxifene phosphate
- Nafoxidine
- Nitromifene
- NNC 45-0095
- NNC 45-0320
- NNC 45-0781
- NNC 45-1506
- Ormeloxifene
- Ospemifene
- Panomifene
- Pipendoxifene
- Promensil
- Raloxifene
- Rimostil (P-081)
- Spironolactone
- SS1010
- Tamoxifen
- TAS-108 (SR-16234)
- Toremifene
- Trioxifene
- TZE-5323
- Y-134
- Zindoxifene
- Zuclomifene
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Antagonists |
- (R,R)-THC
- 7β-Hydroxy-DHEA
- Chloroindazole
- Cytestrol acetate
- EM-800
- Epitiostanol
- ERA-90
- ERB-88
- Fulvestrant (ICI-182780)
Glyceollins (I, II, III, IV)
- ICI-164384
- Mepitiostane
- Methylepitiostanol
- Methylpiperidinopyrazole
- MIBE
- Oxabicycloheptene sulfonate
- Phenytoin
- PHTPP
- Prochloraz
- RU-58668
- SS1020
- TAS-108 (SR-16234)
- ZB716
- ZK-164015
- ZK-191703
Coregulator-binding modulators: ERX-11
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