Melengestrol acetate (MLGA), sold under the brand names Heifermax and MGA among others, is a progestin medication which is used in veterinary medicine.[1][2] It is not approved for use in humans, and is instead used as an implantable contraceptive for captive animals in zoos and other refuges,[3] and is also used as a feed additive to promote growth in cattle, a purpose it is licensed for in the United States and Canada.[4]
Contents
1Uses
1.1Veterinary
2Pharmacology
2.1Pharmacodynamics
3Chemistry
4Society and culture
4.1Generic names
4.2Brand names
5References
Uses
Veterinary
MLGA is used in veterinary medicine.[3][4]
Pharmacology
Pharmacodynamics
MLGA is a progestogen, and hence is an agonist of the progesterone receptor.[5] It has been found to possess 73% of the affinity of progesterone for the progesterone receptor in rhesus monkey uterus.[5]
Chemistry
See also: List of progestogens, Progestogen ester, and List of progestogen esters
MLGA, also known as 17α-acetoxy-16-methylene-6-dehydro-6-methylprogesterone or as 17α-acetoxy-16-methylene-6-methylpregna-4,6-diene-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone.[1][2] It is specifically a derivative of 17α-hydroxyprogesterone with a methyl group at the C6 position, a methylene group at the C16 position, a double bond between the C6 and C7 positions, and an acetate ester at the C17α position.[1][2] As such, it is also a derivative of 16-methylene-17α-hydroxyprogesterone acetate. MLGA is the acetate ester of melengestrol, which in contrast, has never been marketed.[1]Analogues of MLGA include other 17α-hydroxyprogesterone derivatives such as chlormadinone acetate, chlormethenmadinone acetate, cyproterone acetate, delmadinone acetate, hydroxyprogesterone caproate, medroxyprogesterone acetate, megestrol acetate, methenmadinone acetate, and osaterone acetate.[1] The only structural difference between MLGA and megestrol acetate is the presence of the C16 methylene group in the former.[1]
Society and culture
Generic names
Melengestrol acetate is the generic name of the drug and its USAN and USP.[1][2]Melengestrol is the INN and BAN of the unesterified free alcohol form.[1][2]
Brand names
MLGA is marketed under the brand names Heifermax and MGA among others.[1][2]
References
^ abcdefghiJ. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 764–. ISBN 978-1-4757-2085-3..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}
^ abAsa, C.S.; Porton, I.J. (2010). "Chapter 34: Contraception as a Management Tool for Controlling Surplus Animals". In Kleiman, D.G.; Thompson, K.V.; Baer, C.K. Wild Mammals in Captivity: Principles and Techniques for Zoo Management (2nd ed.). Chicago, IL: University of Chicago Press. pp. 469–482. ISBN 9780226440118. Retrieved 17 March 2016.
^ abJack F. Kay (26 November 2009). Analyses for Hormonal Substances in Food-Producing Animals. Royal Society of Chemistry. p. 139. ISBN 978-0-85404-198-5. Retrieved 27 May 2012.
^ abIllingworth DV, Elsner C, De Groot K, Flickinger GL, Mikhail G (February 1977). "A specific progesterone receptor of myometrial cytosol from the rhesus monkey". J. Steroid Biochem. 8 (2): 157–60. PMID 405534.
city in Oromia, Ethiopia Shashamane ሻሸመኔ (in Amharic) , Shashemane (in Oromo) Shashe city Main Street Shashamane Shashamane Location within Ethiopia Coordinates: 7°12′N 38°36′E / 7.200°N 38.600°E / 7.200; 38.600 Country Ethiopia Region Oromia Zone Mirab Arsi Population (2012) • Total 122,046 Time zone UTC+3 (EAT) Climate Cwb Shashamane (or Shashemene , Oromo) is a town and a separate woreda in West Arsi Zone, Oromia Region, Ethiopia. The town lies on the Trans-African Highway 4 Cairo-Cape Town, about 150 miles (240 km) from the capital of Addis Ababa. It has a latitude of 7° 12' north and a longitude of 38° 36' east. The 2007 national census reported a total population for this town of 100,454, of whom 50,654 were men and 49,800 were women. A plurality of the inhabitants practiced Ethiopian Orthodox Christianity, with 43.44% of the population reporting they observed this belief, while 31.15% of the population said
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Deprivation indices are a measure of the level of deprivation in an area. Examples include: Indices of deprivation 2004 (ID2004) Indices of deprivation 2007 (ID2007) Underprivileged area score Carstairs index Department of Environment Index v t e Indices of Deprivation National (general deprivation) Carstairs index Index of Multiple Deprivation 2000 (IMD2000) Indices of deprivation 2004 (ID2004) Indices of deprivation 2007 (ID2007) Indices of deprivation 2010 (ID2010) National (subject specific deprivation) Underprivileged area score Department of Environment Index This economics-related article is a stub. You can help Wikipedia by expanding it. v t e This sociology-related article is a stub. You can help Wikipedia by expanding it. v t e This page is only for reference, If you need detailed information, please check here
