Beraprost













































































Beraprost
Structure of Beraprost.png
Clinical data

AHFS/Drugs.com
 International Drug Names
Routes of
administration		 Oral
ATC code

  • B01AC19 (WHO)

Pharmacokinetic data
Bioavailability 50–70%
Metabolism Unknown
Elimination half-life
 35–40 minutes
Identifiers
CAS Number

  • 88430-50-6 ☑Y88475-69-8

PubChem CID
  • 6917951
IUPHAR/BPS
  • 1967
ChemSpider

  • 5293169 ☑Y
UNII
  • 35E3NJJ4O6
ChEMBL

  • ChEMBL1207745 ☒N
Chemical and physical data
Formula
C24H30O5
Molar mass 398.492 g/mol g·mol−1
3D model (JSmol)
  • Interactive image

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 ☒N☑Y (what is this?)
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Beraprost is a pharmaceutical drug used in several Asian countries, including Japan and South Korea, as a vasodilator and antiplatelet agent.[1] It is classified as a prostacyclin analog.[1][2]


It has been studied for the treatment of pulmonary hypertension and for use in avoiding reperfusion injury.



Clinical pharmacology


As an analog of prostacyclin PGI2, beraprost affects vasodilation, which in turn lowers blood pressure. Beraprost also inhibits platelet aggregation, though the role this phenomenon may play in relation to pulmonary hypertension has yet to be determined.



Dosage and administration


Beraprost is administered orally as a pill available in strength of 20 mcg. Dose ranges from 60 to 180 mcg in divided doses after meals.



References





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  2. ^ Melian EB, Goa KL (2002). "Beraprost: a review of its pharmacology and therapeutic efficacy in the treatment of peripheral arterial disease and pulmonary arterial hypertension". Drugs. 62 (1): 107–33. doi:10.2165/00003495-200262010-00005.















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